The Vaccine Information Sheet (VIS) is a crucial document that provides essential information about vaccines, ensuring that patients or their guardians can make informed decisions about immunization. Issued by the Centers for Disease Control and Prevention (CDC), the VIS explains the benefits and potential risks of a vaccine, details possible side effects, and outlines what to do in case of an adverse reaction. It is legally required to be given before administering certain vaccines, promoting transparency and patient education. By ensuring individuals understand the purpose and safety of vaccinations, the VIS plays a key role in increasing vaccine confidence, improving public health, and preventing the spread of infectious diseases.